In 2008, researchers published a review analyzing the evolutionary dietary balance of different fats in the human diet.

They noted that modern Western diets contain up to 16 times more omega-6 fats than omega-3 fats, a massive imbalance largely driven by the high consumption of seed oils.

The paper tracked how this specific excess of omega-6 polyunsaturated fatty acids promotes the pathogenesis of many modern diseases.

The researchers concluded that this severe dietary imbalance directly drives the development of cardiovascular disease, cancer, and inflammatory diseases, backing the claim that excessive seed oil consumption causes chronic inflammation.

Researchers conducted a 12-week dietary intervention to see what happens when humans purposefully reduce their intake of linoleic acid, which is the most abundant fat in modern seed oils.

They tracked the levels of oxidized linoleic acid metabolites in the participants' blood, looking for compounds that are known markers of stress and damage in the body.

The study found that lowering linoleic acid intake significantly decreased the body's concentration of these oxidized compounds.

Because these specific oxidized metabolites are implicated in driving pathological conditions like cardiovascular disease and chronic pain, the authors concluded that reducing seed oil consumption effectively lowers these disease markers, supporting the claim that seed oils drive inflammatory conditions.